Prior Statin vs In-Hospital Statin Usage in Severe COVID-19: Review and Meta-Analysis.
Curr Probl Cardiol
; 48(9): 101810, 2023 May 19.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2321524
ABSTRACT
Studies have shown that statins can decrease COVID-19 mortality in hospitalized patients. This paper evaluates these studies and reviews the possible mechanism of how statins modulate COVID-19 severity. Meta-analysis of 31 retrospective studies demonstrated a reduction in mortality rate among statin users (OR 0.69, 95% CI 0.56-0.86, Pâ¯=â¯0.0008) (HR 0.83, 95% CI 0.72-0.95, Pâ¯=â¯0.0078). Meta-analysis of 8 randomized control studies demonstrated a nonsignificant reduction in mortality (OR 0.90, 95% CI 0.69-1.18, Pâ¯=â¯0.461), including 4 studies with medications other than statins, and 4 studies with only statins (OR 0.88, 95% CI 95% CI 0.64-1.21, Pâ¯=â¯0.423). Prolonged statin usage decreases the extracellular localization of ACE2, along with statins' immunomodulating effects and reduction of oxidative stress, decreases COVID-19 mortality. Hospitalized patients with COVID-19 should continue statin treatment if previously prescribed, and patients should not be started on statins, as they do not seem to provide any mortality benefit.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Estudio experimental
/
Estudio observacional
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Estudio pronóstico
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Ensayo controlado aleatorizado
/
Revisiones
Idioma:
Inglés
Revista:
Curr Probl Cardiol
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
J.cpcardiol.2023.101810
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