Acute liver injury in COVID-19 patients in Cohort Ward, Somdejphrachaotaksin Maharaj Hospital

ABSTRACT

Objective: To study the prevalence and risk factors for acute liver injury in COVID-19 patients and to assess the clinical outcome of COVID-19 in patients with acute liver injury in cohort ward, Somdejphrachaotaksin Maharaj Hospital. Method(s) A cross-sectional study was done in moderate-to-severe COVID-19 patients who hospitalized in cohort ward, Somdejphrachaotaksin Maharaj Hospital. Demographic data, laboratory results and clinical data were collected during 1st April to 31st October 2021. Result(s) From total of 93 COVID-19 patients, the prevalence of acute liver injury (ALI) were 28% (95%CI 18.6-37.2). Factor associated with acute liver injury was male (p<0.05). Mean absolute lymphocyte count of ALI patients and non-ALI patients were 1154.77 and 1530.02 respectively (p = 0.063). There was no difference in vasopressor support, ventilator support, length of stay and dead of COVID-19 patients between ALI group and non-ALI group. Conclusion(s) The prevalence of acute liver injury among COVID-19 patients was high. Factor associated with acute liver injury were male and tendency of lower absolute lymphocyte count. There were differences in clinical outcome of COVID-19 patients between acute liver injury and non-acute liver injury.