Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Nat Med
; 26(6): 842-844, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1900503
ABSTRACT
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Análisis de la Célula Individual
/
Betacoronavirus
Tipo de estudio:
Estudios diagnósticos
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Nat Med
Asunto de la revista:
Biologia Molecular
/
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
S41591-020-0901-9
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