A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization.
Biochem Biophys Res Commun
; 528(1): 35-38, 2020 07 12.
Artículo
en Inglés
| MEDLINE | ID: covidwho-388951
ABSTRACT
The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave moieties that are located at the three protomer-protomer interfaces. The presence of some druggable pockets at these interfaces suggested that some of the available drugs in Drug Bank could destabilize the quaternary spike glycoprotein formation by binding to these pockets, therefore interfering with COVID-19 life cycle. The approach we propose here can be an additional strategy to fight against the deadly virus. Ligands of COVID-19 spike glycoprotein that we have predicted in the present computational investigation, might be the basis for new experimental studies in vitro and in vivo.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Evaluación Preclínica de Medicamentos
/
Bibliotecas de Moléculas Pequeñas
/
Multimerización de Proteína
/
Glicoproteína de la Espiga del Coronavirus
/
Betacoronavirus
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Tópicos:
Medicina tradicional
Idioma:
Inglés
Revista:
Biochem Biophys Res Commun
Año:
2020
Tipo del documento:
Artículo
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