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Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: a case report.
Xu, Tian-Min; Lin, Bin; Chen, Cong; Liu, Long-Gen; Xue, Yuan.
  • Xu TM; Department of Infectious Diseases, the Third People's Hospital of Changzhou, Changzhou, Jiangsu, China.
  • Lin B; Department of Infectious Diseases, the First People's Hospital of Jintan, Changzhou, Jiangsu, China.
  • Chen C; Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu, China.
  • Liu LG; Institute of Hepatology, the Third People's Hospital of Changzhou, No. 300 Lanling North Road, Changzhou, 213000, Jiangsu, China.
  • Xue Y; Institute of Hepatology, the Third People's Hospital of Changzhou, No. 300 Lanling North Road, Changzhou, 213000, Jiangsu, China. xueyuan80908@163.com.
Virol J ; 17(1): 80, 2020 06 19.
Artículo en Inglés | MEDLINE | ID: covidwho-606695
ABSTRACT

BACKGROUND:

Convalescent plasma (CP) transfusion was reported to be effective in treating critically ill patients with COVID-19, and hydroxychloroquine could potently inhibit SARS-CoV-2 in vitro. Herein, we reported a case receiving combination therapy with CP transfusion and hydroxychloroquine for the first time. CASE PRESENTATION Laboratory findings showed high lactic acid level (2.1 mmol/L) and C-reactive protein (CRP, 48.8 mg/L), and low white blood cell count (1.96 × 109/L) in a 65-year-old Chinese man, who was diagnosed with severe COVID-19. CP was intravenously given twice, and hydroxychloroquine was orally administrated for a week (0.2 g, three times a day). The lactic acid and C-reactive protein levels remained high (2.1 mmol/L and 73.23 mg/L, respectively), while the arterial oxyhemoglobin saturation decreased to 86% with a low oxygenation index (OI, 76 mmHg) on day 4 after CP transfusion. His temperature returned to normal and the OI ascended above 300 on day 11. Moreover, the RNA test remained positive in throat swab, and computed tomography revealed severe pulmonary lesions on day 11 after admission.

CONCLUSION:

These findings suggested that the effectiveness of combination therapy with CP and hydroxychloroquine may be non-optimal, and specific therapy needs to be explored.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Transfusión de Componentes Sanguíneos / Infecciones por Coronavirus / Hidroxicloroquina Tipo de estudio: Reporte de caso / Estudio experimental Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Virol J Asunto de la revista: Virología Año: 2020 Tipo del documento: Artículo País de afiliación: S12985-020-01354-6

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Transfusión de Componentes Sanguíneos / Infecciones por Coronavirus / Hidroxicloroquina Tipo de estudio: Reporte de caso / Estudio experimental Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Virol J Asunto de la revista: Virología Año: 2020 Tipo del documento: Artículo País de afiliación: S12985-020-01354-6