Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Biomed Res Int
; 2020: 1594726, 2020.
Artículo
en Inglés
| MEDLINE | ID: covidwho-633800
ABSTRACT
Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds. It has a variety of beneficial properties including anti-inflammatory and antioxidative activities. Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB/c mice. Eight-week-old male BALB/c mice were divided into four groups control, TQ, cecal ligation and puncture (CLP), and TQ+CLP. CLP was performed after 2 weeks of TQ gavage. After 48 h, we measured the histopathological alterations in the kidney tissue and the serum levels of creatinine (CRE) and blood urea nitrogen (BUN). We also evaluated pyroptosis (NLRP3, caspase-1), apoptosis (caspase-3, caspase-8), proinflammatory (TNF-α, IL-1ß, and IL-6)-related protein and gene expression levels. Our results demonstrated that TQ inhibited CLP-induced increased serum CRE and BUN levels. It also significantly inhibited the high levels of NLRP3, caspase-1, caspase-3, caspase-8, TNF-α, IL-1ß, and IL-6 induced by CLP. Furthermore, NF-κB protein level was significantly decreased in the TQ+CLP group than in the CLP group. Together, our results indicate that TQ may be a potential therapeutic agent for sepsis-induced AKI.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Benzoquinonas
/
Sepsis
/
Lesión Renal Aguda
Tipo de estudio:
Estudio experimental
/
Ensayo controlado aleatorizado
Tópicos:
Covid persistente
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Biomed Res Int
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
2020
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