COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor.
Prog Urol
; 30(10): 484-487, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: covidwho-634109
ABSTRACT
COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Receptores Virales
/
Serina Endopeptidasas
/
Receptores Androgénicos
/
Infecciones por Coronavirus
/
Peptidil-Dipeptidasa A
/
Pandemias
/
Betacoronavirus
Tipo de estudio:
Estudio observacional
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Prog Urol
Asunto de la revista:
Urología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
J.purol.2020.05.007
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