Comprehensive analysis of drugs to treat SARSCoV2 infection: Mechanistic insights into current COVID19 therapies (Review).
Int J Mol Med
; 46(2): 467-488, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: covidwho-678269
ABSTRACT
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARSCoV2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Internalización del Virus
/
Reposicionamiento de Medicamentos
/
Betacoronavirus
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
/
Revisiones
Idioma:
Inglés
Revista:
Int J Mol Med
Asunto de la revista:
Biologia Molecular
/
Genética Médica
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Ijmm.2020.4608
Similares
MEDLINE
...
LILACS
LIS