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A drug screening toolkit based on the -1 ribosomal frameshifting of SARS-CoV-2.
Chen, Yanqiong; Tao, Huan; Shen, Silan; Miao, Zhiyong; Li, Lili; Jia, Yongqian; Zhang, Hu; Bai, Xiufeng; Fu, Xinyuan.
  • Chen Y; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.
  • Tao H; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
  • Shen S; Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Miao Z; Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Li L; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
  • Jia Y; Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Zhang H; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.
  • Bai X; Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Fu X; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Heliyon ; 6(8): e04793, 2020 Aug.
Artículo en Inglés | MEDLINE | ID: covidwho-737782
ABSTRACT
The -1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to successfully develop a toolkit for screening antiviral drugs. Finally, the FDA-approved drug library was screened, revealing that ivacaftor and (-)-Huperzine A worked well in changing the -1 ribosomal frameshifting of SARS-CoV-2 in vitro.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Heliyon Año: 2020 Tipo del documento: Artículo País de afiliación: J.heliyon.2020.e04793

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Heliyon Año: 2020 Tipo del documento: Artículo País de afiliación: J.heliyon.2020.e04793