Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147).
Mol Biol Rep
; 47(10): 8229-8233, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: covidwho-754391
ABSTRACT
COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible for the cytokine storm in the lungs through the mediation of viral invasion. Melatonin use previously was shown to reduce cardiac damage by blocking the CD147 activity. Hence, melatonin, a safe drug, may prevent severe symptoms, reduce symptom severity and the adverse effects of the other antiviral drugs in COVID-19 patients. In conclusion, the use of melatonin, which is reduced in the elderly and immune-compromised patients, should be considered as an adjuvant through its CD147 suppressor and immunomodulatory effect.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Neumonía Viral
/
Adyuvantes Farmacéuticos
/
Infecciones por Coronavirus
/
Basigina
/
Melatonina
Tipo de estudio:
Estudio experimental
/
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mol Biol Rep
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
S11033-020-05830-8
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