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Risk factors for prolonged viral clearance in adult patients with COVID-19 in Beijing, China: A prospective observational study.
Xue, Jian; Zheng, Jing; Shang, Xueyi; Qin, Enqiang; Zhao, Peng; He, Yuan; Liu, Mengyang; Zhang, Jin; Liu, Huiying; Bai, Changqing.
  • Xue J; Department of Cardiology, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Zheng J; Department of Respiratory and Critical Care Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Shang X; Department of Critical Care Medicine, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Qin E; Treatment and Research Center for Infectious Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Zhao P; Treatment and Research Center for Infectious Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • He Y; Department of Respiratory and Critical Care Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Liu M; School of Public Health, Capital Medical University, Beijing 100069, China.
  • Zhang J; Department of Cardiology, 5th Center of Chinese PLA General Hospital, Beijing 100071, China.
  • Liu H; Department of Respiratory and Critical Care Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China. Electronic address: liuhuiying1982@sina.com.
  • Bai C; Department of Respiratory and Critical Care Diseases, 5th Center of Chinese PLA General Hospital, Beijing 100071, China; Department of Respiratory, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Guangdong 518055, China. Electronic address: baicq307@163.com.
Int Immunopharmacol ; 89(Pt A): 107031, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: covidwho-785793
ABSTRACT
Clearance of COVID-19 from the human body has not been established. Our study collected the laboratory test results from patients and analyzed the correlation between early changes in serum indices and the virus clearance by univariable and multivariable COX regression models, with an aim to explore the risk factors for prolonged viral clearance. The study included 61 patients with COVID-19 treated at the Fifth Medical Center of PLA General Hospital in Beijing from 20 January 2020 to 20 February 2020. We set the total observation of the disease course to 20 days and the patients were divided into two groups (prolonged group, > 20d vs. normal group, ≤ 20d). The 48 patients with COVID-19 included in this study, 13 remained positive for viral nucleic acid monitoring 20 days after onset. The median for virus clearance was 16 days (range, 6-35 days). The results showed that hypertension, a lactate dehydrogenase level > 211.5 U/L, an interleukin 6 (IL-6) level > 12.5 pg/ml, and a NK lymphocyte percentage > 0.5% were associated with prolonged viral clearance. Therefore, we showed that a history of hypertension, an elevated IL-6 level, and an elevated percentage of NK cells were risk factors for prolonged viral clearance.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: ARN Viral / Esparcimiento de Virus / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio de cohorte / Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: Int Immunopharmacol Asunto de la revista: Alergia e Inmunología / Farmacología Año: 2020 Tipo del documento: Artículo País de afiliación: J.intimp.2020.107031

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: ARN Viral / Esparcimiento de Virus / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio de cohorte / Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: Int Immunopharmacol Asunto de la revista: Alergia e Inmunología / Farmacología Año: 2020 Tipo del documento: Artículo País de afiliación: J.intimp.2020.107031