Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.
Curr Top Med Chem
; 20(26): 2362-2378, 2020.
Artículo
en Inglés
| MEDLINE | ID: covidwho-789061
ABSTRACT
The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a Receptor-binding Domain (RBD) that mediates the binding to host cell receptor, Angiotensin Converting Enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of Convalescent Plasma (CP) therapy to treat COVID-19 is also discussed.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Neumonía Viral
/
Infecciones por Coronavirus
/
Peptidil-Dipeptidasa A
/
Pandemias
/
Glicoproteína de la Espiga del Coronavirus
Tipo de estudio:
Estudios diagnósticos
/
Estudio observacional
Tópicos:
Vacunas
Idioma:
Inglés
Revista:
Curr Top Med Chem
Asunto de la revista:
Química
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
1568026620666200922112300
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