Could Sars-Cov2 affect MS progression?

Di Stadio, Arianna; Romani, Luigina; Bernitsas, Evanthia

Di Stadio, Arianna; Romani, Luigina; Bernitsas, Evanthia.

Di Stadio A; Otolaryngology Department, University of Perugia, Perugia, Italy; Neuroinflammation Lab, Queen Square UCL Neurology, London, UK. Electronic address: Arianna.distadio@unipg.it.
Romani L; Department of Experimental Medicine, University of Perugia, Perugia, Italy.
Bernitsas E; Multiple Sclerosis Center, Wayne State University, Detroit (MI), USA.

Mult Scler Relat Disord ; 46: 102540, 2020 Nov.

Artículo en Inglés | MEDLINE | ID: covidwho-803007

ABSTRACT

ABSTRACT

A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2. These two mechanisms may cause a worsening of MS several months after the resolution of the infection.

Asunto(s)

COVID-19/virología; Inflamasomas/metabolismo; Esclerosis Múltiple/complicaciones; SARS-CoV-2/patogenicidad; COVID-19/complicaciones; COVID-19/metabolismo; Progresión de la Enfermedad; Humanos; Interleucina-1beta/metabolismo; Interleucina-1beta/farmacología; Esclerosis Múltiple/virología

Palabras clave

COVID-19; Inflammasomes; Long-term sequela; Microglia; Sars-CoV2, Multiple sclerosis

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Inflamasomas / SARS-CoV-2 / COVID-19 / Esclerosis Múltiple Tópicos: Covid persistente Límite: Humanos Idioma: Inglés Revista: Mult Scler Relat Disord Año: 2020 Tipo del documento: Artículo

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