Endothelial Dysfunction and Thrombosis in Patients With COVID-19-Brief Report.
Arterioscler Thromb Vasc Biol
; 40(10): 2404-2407, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1015733
ABSTRACT
OBJECTIVE:
Alveolar-capillary endothelial cells can be activated by severe acute respiratory syndrome coronavirus 2 infection leading to cytokine release. This could trigger endothelial dysfunction, pyroptosis, and thrombosis, which are the vascular changes, commonly referred to as coronavirus disease 2019 (COVID-19) endotheliopathy. Thus, this study aimed to identify tissue biomarkers associated with endothelial activation/dysfunction and the pyroptosis pathway in the lung samples of patients with COVID-19 and to compare them to pandemic influenza A virus H1N1 subtype 2009 and control cases. Approach andResults:
Postmortem lung samples (COVID-19 group =6 cases; H1N1 group =10 cases, and control group =11 cases) were analyzed using immunohistochemistry and the following monoclonal primary antibodies anti-IL (interleukin)-6, anti-TNF (tumor necrosis factor)-α, anti-ICAM-1 (intercellular adhesion molecule 1), and anticaspase-1. From the result, IL-6, TNF-α, ICAM-1, and caspase-1 showed higher tissue expression in the COVID-19 group than in the H1N1 and control groups.CONCLUSIONS:
Our results demonstrated endothelial dysfunction and suggested the participation of the pyroptosis pathway in the pulmonary samples. These conditions might lead to systemic thrombotic events that could impair the clinical staff's efforts to avoid fatal outcomes. One of the health professionals' goals should be to identify the high risk of thrombosis patients early to block endotheliopathy and its consequences.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Trombosis
/
Enfermedades Vasculares
/
Endotelio Vascular
/
Infecciones por Coronavirus
/
Células Endoteliales
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arterioscler Thromb Vasc Biol
Asunto de la revista:
Angiología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
ATVBAHA.120.314860
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