Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science
; 370(6521)2020 12 04.
Artículo
en Inglés
| MEDLINE | ID: covidwho-873450
ABSTRACT
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Síndrome Respiratorio Agudo Grave
/
Proteínas de Transporte de Membrana Mitocondrial
/
Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo
/
Mapas de Interacción de Proteínas
/
Interacciones Microbiota-Huesped
/
Proteínas de la Nucleocápside de Coronavirus
/
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Science.abe9403
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