COVID-19 and Major Organ Thromboembolism: Manifestations in Neurovascular and Cardiovascular Systems.
J Stroke Cerebrovasc Dis
; 30(1): 105427, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: covidwho-899242
ABSTRACT
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause multisystemic damage. We undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in COVID-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. The presence of thrombosis in multiple organ systems points to thromboembolism being an integral component in the pathogenesis of this disease. Thromboembolism is likely to be the main player in the morbidity and mortality of COVID -19 in which the pulmonary system is most severely affected. We also hypothesize that D-dimer values could be used as an early marker for prognostication of disease as it has been seen to be raised even in the pre-symptomatic stage. This further strengthens the notion that thromboembolism prevention is necessary. We also examined literature on the neurovascular and cardiovascular systems, as the manifestation of thromboembolic phenomenon in these two systems varied, suggesting different pathophysiology of damage. Further research into the role of thromboembolism in COVID-19 is important to advance the understanding of the virus, its effects and to tailor treatment accordingly to prevent further casualties from this pandemic.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Arteriopatías Oclusivas
/
Embolia Pulmonar
/
Trastornos Cerebrovasculares
/
Trombosis de la Vena
/
Tromboembolia Venosa
/
COVID-19
Tipo de estudio:
Estudios diagnósticos
/
Estudio pronóstico
/
Revisiones
/
Revisión sistemática/Meta análisis
Tópicos:
Covid persistente
Límite:
Humanos
Idioma:
Inglés
Revista:
J Stroke Cerebrovasc Dis
Asunto de la revista:
Angiología
/
Cérebro
Año:
2021
Tipo del documento:
Artículo
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