Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach.
ACS Chem Neurosci
; 11(22): 3701-3703, 2020 11 18.
Artículo
en Inglés
| MEDLINE | ID: covidwho-899862
ABSTRACT
Cell entry, the fundamental step in cross-species transmission of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is initiated by the recognition of the host cell angiotensin-converting enzyme-2 (ACE2) receptor by the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. To date, several peptides have been proposed against SARS-CoV-2 both as inhibitor agents or as detection tools that can also be attached to the surfaces of nanoparticle carriers. But owing to their natural amino acid sequences, such peptides cannot be considered as efficient therapeutic candidates from a biostability point of view. This discussion demonstrates the design strategy of synthetic nonprotein amino acid substituted peptides with enhanced biostability and binding affinity, the implication of which can make those peptides potential therapeutic agents for inhibition and simple detection tools.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Fragmentos de Péptidos
/
Neumonía Viral
/
Diseño de Fármacos
/
Infecciones por Coronavirus
/
Betacoronavirus
Tipo de estudio:
Ensayo controlado aleatorizado
Límite:
Humanos
Idioma:
Inglés
Revista:
ACS Chem Neurosci
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS