Step toward repurposing drug discovery for COVID-19 therapeutics through in silico approach.
Drug Dev Res
; 82(3): 374-392, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-917089
ABSTRACT
The outbreak of SARS-CoV-2 has become a threat to global health and has led to a global economic crisis. Although the researchers worldwide are putting tremendous effort toward gaining more insights into this zoonotic virus and developing vaccines and therapeutic drugs, no vaccine or drug is yet available to combat COVID-19 effectively. Drug discovery is often a laborious, time-consuming, and expensive task. In this time of crisis, employing computational methods could provide a feasible alternative approach that can potentially be used for drug discovery. Therefore, a library of several antiparasitic and anti-inflammatory drugs was virtually screened against SARS-CoV-2 proteases to identify potential inhibitors. The identified inhibitory drugs were further analyzed to confirm their activities against SARS-CoV-2. Our results could prove to be helpful in repurposing the drug discovery approach, which could substantially reduce the expenses, time, and resources required.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Descubrimiento de Drogas
/
Reposicionamiento de Medicamentos
/
Tratamiento Farmacológico de COVID-19
Tópicos:
Vacunas
Límite:
Humanos
Idioma:
Inglés
Revista:
Drug Dev Res
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Ddr.21757
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