Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic.
Aging (Albany NY)
; 12(23): 24453-24461, 2020 11 10.
Artículo
en Inglés
| MEDLINE | ID: covidwho-927217
ABSTRACT
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) uses the angiotensin-converting enzyme 2 (ACE2) receptor for infecting and spreading in humans. Studies have shown that the widespread expression of ACE2 in human tissues may be associated with organ function damage (e.g., lung, kidney, and stomach) in patients with coronavirus disease 2019 (COVID-19). However, in neurodegenerative diseases, whose pathogenesis is closely related to advanced age, ACE2 plays a neurotrophic and protective role by activating the ACE2/Ang-(1-7)/Mas axis, thus inhibiting cognitive impairment. Early reports have revealed that the elderly are more susceptible to COVID-19 and that elderly patients with COVID-19 have faster disease progression and higher mortality. Therefore, during the COVID-19 pandemic, it is crucial to understand the role of ACE2 in neurodegenerative diseases. In this paper, we review the relationship between COVID-19, neurodegenerative diseases, and ACE2, as well as provide recommendations for the protection of elderly patients with neurodegenerative diseases during the COVID-19 pandemic.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Enzima Convertidora de Angiotensina 2
/
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Humanos
Idioma:
Inglés
Revista:
Aging (Albany NY)
Asunto de la revista:
Geriatria
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Aging.103993
Similares
MEDLINE
...
LILACS
LIS