Investigation of QT Prolongation with Hydroxychloroquine and Azithromycin for the Treatment of COVID-19.
J Coll Physicians Surg Pak
; 30(10): 153-157, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: covidwho-969258
ABSTRACT
OBJECTIVE:
To assess and identify the risk of prolonged QT about hydroxychloroquine (HQ) and azithromycin (AZ) used in the treatment of patients with COVID-19. STUDYDESIGN:
Cohort study. PLACE AND DURATION OF STUDY Kartal Dr. Lütfi Kirdar City Hospital, Istanbul, Turkey, from March to May 2020.METHODOLOGY:
One hundred and forty-four patients with the diagnosis of COVID-19, confirmed by Rt-PCR (reverse transcription-polymerase chain reaction), were restrospectively reviewed. Patients who were hospitalised, received HQ or HQ plus AZ treatment, had a baseline electrocardiogram (ECG), and had at least one ECG after treatment were included in the study. Patients with missing data were excluded.RESULTS:
Fifty-one (35.4%) patients were given hydroxychloroquine monoterapy (HQ), 93 (64.6%) were given hydroxychloroquine plus azithromycin (HA), and 70 (48.6%) were women. Pre-treatment mean QTc measurements were calculated as 410.61 ± 29.44 milliseconds (ms) for HQ group and 412.02 ± 25.37 ms for HA group, while the mean values of post-treatment QTc measurements were calculated as 432.31 ± 33.97 ms for HQ group and 432.03 ± 27.0 ms for the HA group. Post-treatment QTc measurements of both HA group and HQ group were prolonged compared to pre-treatment measurements. Ventricular arrhythmia was not observed in any patient.CONCLUSION:
For COVID-19, no globally accepted definite treatment has yet been found. Both of hydroxychloroquine monotherapy and hydroxychloroquine plus azithromycin treatment regimens cause QTc measurement to increase at a statistically significant level. We concluded that this increase in QTc did not cause ventricular arrhythmia. Key Words COVID-19, QTc interval, Hydroxychloroquine, Azithromycin.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Síndrome de QT Prolongado
/
Azitromicina
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Electrocardiografía
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Pandemias
/
SARS-CoV-2
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Tratamiento Farmacológico de COVID-19
/
Hidroxicloroquina
Tipo de estudio:
Estudio de cohorte
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Middle aged
/
Young_adult
Idioma:
Inglés
Revista:
J Coll Physicians Surg Pak
Asunto de la revista:
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Jcpsp.2020.supp2.S153
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