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Impact of Diabetes in Patients Diagnosed With COVID-19.
Abu-Farha, Mohamed; Al-Mulla, Fahd; Thanaraj, Thangavel Alphonse; Kavalakatt, Sina; Ali, Hamad; Abdul Ghani, Mohammed; Abubaker, Jehad.
  • Abu-Farha M; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
  • Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman, Kuwait.
  • Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman, Kuwait.
  • Kavalakatt S; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
  • Ali H; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman, Kuwait.
  • Abdul Ghani M; Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Center, Kuwait University, Jabriya, Kuwait.
  • Abubaker J; Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Front Immunol ; 11: 576818, 2020.
Artículo en Inglés | MEDLINE | ID: covidwho-993354
ABSTRACT
COVID-19 is a disease caused by the coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), known as a highly contagious disease, currently affecting more than 200 countries worldwide. The main feature of SARS-CoV-2 that distinguishes it from other viruses is the speed of transmission combined with higher risk of mortality from acute respiratory distress syndrome (ARDS). People with diabetes mellitus (DM), severe obesity, cardiovascular disease, and hypertension are more likely to get infected and are at a higher risk of mortality from COVID-19. Among elderly patients who are at higher risk of death from COVID-19, 26.8% have DM. Although the reasons for this increased risk are yet to be determined, several factors may contribute to type-2 DM patients' increased susceptibility to infections. A possible factor that may play a role in increasing the risk in people affected by diabetes and/or obesity is the impaired innate and adaptive immune response, characterized by a state of chronic and low-grade inflammation that can lead to abrupt systemic metabolic alteration. SARS patients previously diagnosed with diabetes or hyperglycemia had higher mortality and morbidity rates when compared with patients who were under metabolic control. Similarly, obese individuals are at higher risk of developing complications from SARS-CoV-2. In this review, we will explore the current and evolving insights pertinent to the metabolic impact of coronavirus infections with special attention to the main pathways and mechanisms that are linked to the pathophysiology and treatment of diabetes.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Complicaciones de la Diabetes / Inmunidad Adaptativa / Inmunidad Innata / Obesidad Tipo de estudio: Estudio experimental / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos Idioma: Inglés Revista: Front Immunol Año: 2020 Tipo del documento: Artículo País de afiliación: Fimmu.2020.576818

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Complicaciones de la Diabetes / Inmunidad Adaptativa / Inmunidad Innata / Obesidad Tipo de estudio: Estudio experimental / Estudio pronóstico Tópicos: Covid persistente Límite: Humanos Idioma: Inglés Revista: Front Immunol Año: 2020 Tipo del documento: Artículo País de afiliación: Fimmu.2020.576818