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Genetically determined serum testosterone level and Covid-19 illness level: A mendelian randomization study (preprint)
medrxiv; 2021.
Preprint
en Inglés
| medRxiv | ID: ppzbmed-10.1101.2021.10.10.21264779
ABSTRACT
Background:
It is hypothesized that different levels of hormones especially serum testosterone level could explain the sex differences between men and women on the susceptibility and case fatality rate of COVID-19. However, traditional observational studies that support this hypothesis could not effectively establish the causal effects.Objective:
Utilizing recently published genome-wide associations studies (GWAS) on serum Testosterone level and on COVID-19 related phenotypes, we sought to assess the causality through Mendelian Randomization (MR) analyses. We further applied a suite of statistical genomics methods to further explore the biological mechanisms.Results:
We found that testosterone level is significantly associated with Covid-19 critical illness. All six MR methods yielded significant associations. There is no significant association between Testosterone and COVID-19 respiratory failure or COVID-19 susceptibility.Conclusion:
Based on the GWAS currently available, we provide support for a causal role of Testosterone on COVID-19 critical illness. Nevertheless, we recognize that the COVID-19 susceptibility GWAS effort is still ongoing and there is no such strong locus as CCR5 for HIV discovered for COVID-19.
Texto completo:
Disponible
Colección:
Preprints
Base de datos:
medRxiv
Asunto principal:
Insuficiencia Respiratoria
/
COVID-19
Idioma:
Inglés
Año:
2021
Tipo del documento:
Preprint
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