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Computational fitness estimates of SARS-CoV-2 mutations affecting spike protein binding to antibodies and ACE2 (preprint)
biorxiv; 2023.
Preprint
en Inglés
| bioRxiv | ID: ppzbmed-10.1101.2023.05.01.538902
ABSTRACT
Predicting the impact of new emerging virus mutations is of major interest in surveillance and for understanding the evolutionary forces of the pathogen. The SARS-CoV-2 surface spike-protein (S-protein) binds to human ACE2 receptors as a critical step in host cell infection. At the same time, S-protein binding to human antibodies neutralizes the virus and prevents interaction with ACE2. Here we combine these two binding properties in a simple fitness model, using structure-based computation of all possible mutation effects averaged over 10 ACE2 complexes and 10 antibody complexes of the S-protein. The ACE2-antibody selectivity change caused by mutation (i.e., the change binding to ACE2 minus the change in binding to immunity-inducing antibodies) is proposed to be a key metric of virus fitness, which furthermore enables substantial systematic error cancelation when evaluated. In this model, new mutations become fixated if they increase the selective binding to ACE2 relative to circulating antibodies, assuming that both are present in the host in a competitive binding situation. We use this model to categorize viral mutations that may best reach ACE2 before being captured by antibodies. Our model may aid the understanding of variant-specific vaccines and molecular mechanisms of viral evolution in the context of a human host.
Texto completo:
Disponible
Colección:
Preprints
Base de datos:
bioRxiv
Asunto principal:
Virosis
/
Carcinoma de Células Renales
/
Epilepsias Parciales
Idioma:
Inglés
Año:
2023
Tipo del documento:
Preprint
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