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A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge (preprint)
researchsquare; 2020.
Preprint en Inglés | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-35891.v1
ABSTRACT
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we found that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protected mice completely against SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protected ferrets from SARS-CoV-2 infection in the upper respiratory tract. This study suggested that a combination of intramuscular and mucosal vaccination maybe provide a desirable protective efficacy and different Ad5-nCoV delivery modes are worth further investigation in human clinical trials.
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Texto completo: Disponible Colección: Preprints Base de datos: PREPRINT-RESEARCHSQUARE Asunto principal: Enfermedades Transmisibles / COVID-19 Idioma: Inglés Año: 2020 Tipo del documento: Preprint

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Texto completo: Disponible Colección: Preprints Base de datos: PREPRINT-RESEARCHSQUARE Asunto principal: Enfermedades Transmisibles / COVID-19 Idioma: Inglés Año: 2020 Tipo del documento: Preprint