Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry.
BMC Neurol
; 21(1): 43, 2021 Jan 30.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1054807
ABSTRACT
BACKGROUND AND PURPOSE:
Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology.METHODS:
We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20).RESULTS:
Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p=0.05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5.16, 95%CI 1.41-18.87, p = 0.01). In that model, older age (aOR 2.05 per decade, 95%CI 1.35-3.11, p < 0.01) and higher baseline NIHSS (aOR 1.12, 95%CI 1.02-1.21, p = 0.01) were also independently predictive of mortality.CONCLUSIONS:
Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality.Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Enregistrements
/
Mortalité hospitalière
/
Accident vasculaire cérébral ischémique
/
COVID-19
Type d'étude:
Étude de cohorte
/
Étude d'étiologie
/
Études expérimentales
/
Étude observationnelle
/
Étude pronostique
Les sujets:
Covid long
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
/
Adulte d'âge moyen
Pays comme sujet:
Afrique
/
Amérique du Nord
/
Europe
langue:
Anglais
Revue:
BMC Neurol
Thème du journal:
Neurologie
Année:
2021
Type de document:
Article
Pays d'affiliation:
S12883-021-02075-1
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