Biological function of furin in viral infections
Zhongguo Bingdubing Zazhi = Chinese Journal of Viral Diseases
; - (3):209, 2021.
Article
Dans Anglais
| ProQuest Central | ID: covidwho-1329332
ABSTRACT
Most viruses require their glycoproteins to be hydrolyzed in order to enter host cells.In some cases, the severability of viral glycoproteins is a determinant of their virulence.These viral glycoproteins can be cleaved by one or more proteases in host cells with furin as the common one.Furin further promotes viral infection by identifying specific amino acid sequences in glycoprotein precursors.Morever, furin plays a critical role in the infections of many viruses including human immunodeficiency virus, flavivirus, filamentavirus and coronavirus, and is considered as a promising drug treatment and prevention target.In this review, we summarize the biological background of furin and its hydrolysis function to viral glycoproteins.
Collection:
Bases de données des oragnisations internationales
Base de données:
ProQuest Central
langue:
Anglais
Revue:
Zhongguo Bingdubing Zazhi = Chinese Journal of Viral Diseases
Année:
2021
Type de document:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS