Malignant cerebral infarction after ChAdOx1 nCov-19 vaccination: a catastrophic variant of vaccine-induced immune thrombotic thrombocytopenia.
Nat Commun
; 12(1): 4663, 2021 08 02.
Article
Dans Anglais
| MEDLINE | ID: covidwho-1338537
ABSTRACT
Vaccine-induced thrombotic thrombocytopenia with cerebral venous thrombosis is a syndrome recently described in young adults within two weeks from the first dose of the ChAdOx1 nCoV-19 vaccine. Here we report two cases of malignant middle cerebral artery (MCA) infarct and thrombocytopenia 9-10 days following ChAdOx1 nCoV-19 vaccination. The two cases arrived in our facility around the same time but from different geographical areas, potentially excluding epidemiological links; meanwhile, no abnormality was found in the respective vaccine batches. Patient 1 was a 57-year-old woman who underwent decompressive craniectomy despite two prior, successful mechanical thrombectomies. Patient 2 was a 55-year-old woman who developed a fatal bilateral malignant MCA infarct. Both patients manifested pulmonary and portal vein thrombosis and high level of antibodies to platelet factor 4-polyanion complexes. None of the patients had ever received heparin in the past before stroke onset. Our observations of rare arterial thrombosis may contribute to assessment of possible adverse effects associated with COVID-19 vaccination.
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Thrombose
/
Infarctus cérébral
/
Purpura thrombopénique idiopathique
/
Vaccins contre la COVID-19
/
SARS-CoV-2
/
COVID-19
Type d'étude:
Rapport de cas
/
Étude observationnelle
/
Étude pronostique
Les sujets:
Vaccins
/
Variantes
Limites du sujet:
Femelle
/
Humains
/
Adulte d'âge moyen
langue:
Anglais
Revue:
Nat Commun
Thème du journal:
Biologie
/
Science
Année:
2021
Type de document:
Article
Pays d'affiliation:
S41467-021-25010-x
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