[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].
Ter Arkh
; 94(1): 32-47, 2022 Jan 15.
Article
Dans Russe
| MEDLINE | ID: covidwho-1798590
ABSTRACT
AIM:
Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. MATERIALS ANDMETHODS:
The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry men and women with COVID-19 treated at hospital or at home. CLINICALTRIALS gov ID NCT04492384.RESULTS:
Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.CONCLUSION:
Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Maladies cardiovasculaires
/
Maladie coronarienne
/
Diabète
/
Maladies non transmissibles
/
COVID-19
/
Défaillance cardiaque
/
Hypertension artérielle
Type d'étude:
Étude diagnostique
/
Études expérimentales
/
Étude observationnelle
/
Étude pronostique
Les sujets:
Variantes
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Russe
Revue:
Ter Arkh
Année:
2022
Type de document:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS