New definition of RIME: Mucocutaneous eruptions, bullous lesions and multi-mucosal involvement
Pediatric Dermatology
; 40(Supplement 2):28, 2023.
Article
Dans Anglais
| EMBASE | ID: covidwho-20237133
ABSTRACT
Objectives:
A 14-year-old female patient presents with marked haemorrhagic, adherent crusting of the upper and lower lip and enoral vesicles and erosions. Two weeks before, she had suffered from a respiratory tract infection. She did not take antibiotics but ibuprofen. One week later, she described a swelling and crusting of the upper and lower lips. Urogenital mucosa was also erosive. There was no ocular involvement. Another week later, cocard-like single lesions with partly central blister formation developed. A flaccid blister of 15 mm in diameter was detected in the left ear helix. In total, there was a limited cutaneous involvement of <10% BSA. The girl was admitted to the paediatric clinic. Method(s) Due to mucocutaneous eruptions, bullous lesions and multimucosal involvement, we assumed a Steven-Johnson syndrome or reactive infectious mucocutaneous eruption (RIME). Intravenous rehydration and prophylactic administration of cefotaxime and aciclovir were given. She was balanced and given analgesia with novalgin. The recent increased intake of ibuprofen was discontinued. Local therapy included mometasone cream and serasept dressings. During the inpatient stay, the general condition stabilised and the skin efflorescence's showed a clear regression. Result(s) The microbiological smears for COVID-19, HSV, VZV, mycoplasma, and chlamydia were negative. Discussion(s) As adult classifications for blistering severe cutaneous adverse reactions are limited applicable in children, Ramien et al. proposed revised paediatric-focused clinical criteria 2021. They leave traditional definitions of EEM, SJS and TEN. But they distinguish erythema multiforme (EM) for classic targets with/without mucosal involvement, RIME for cases with mucosal predominance and a respiratory infection trigger, and drug-induced epidermal necrolysis (DEN) for cases caused by medications. (Ramien BJD 2021) There are no current guidelines for RIME therapy. A reasonable management approach includes symptomatic therapy, treatment of identifiable infectious triggers (if possible), consulting urologists, ophthalmologists and gynaecologists (if necessary), immunosuppression, and psychological support. (Ramien ClinExpDermatol 2021).
adolescent; adult; adverse drug reaction; analgesia; blister; case report; child; Chlamydia; clinical article; conference abstract; coronavirus disease 2019; drug combination; drug therapy; ear; erosion; erythema multiforme; female; general condition; gynecologist; hospital patient; human; immunosuppressive treatment; local therapy; lower lip; mucosa; Mycoplasma; nonhuman; ophthalmologist; pediatric hospital; practice guideline; psychological care; rehydration; respiratory tract infection; side effect; Stevens Johnson/toxic epidermal necrolysis overlap syndrome; swelling; upper lip; urologist; Varicella zoster virus; aciclovir; antibiotic agent; cefotaxime; dipyrone; ibuprofen; mometasone furoate
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
EMBASE
Type d'étude:
Étude pronostique
langue:
Anglais
Revue:
Pediatric Dermatology
Année:
2023
Type de document:
Article
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