COVID-19 associated severe mucocutaneous blistering eruptions: A case series
Pediatric Dermatology
; 40(Supplement 1):26-27, 2023.
Article
Dans Anglais
| EMBASE | ID: covidwho-20239756
ABSTRACT
Introduction:
Mucocutaneous eruptions are associated with many viral processes and present as erythema multiforme (EM), reactive infectious mucocutaneous eruption (RIME), Stevens Johnson syndrome (SJS) or toxic epidermal necrosis (TEN). Limited reports have described the association of COVID-19 and mucocutaneous eruptions in children and adults to date. Method(s) This was a multicenter descriptive case series performed at six tertiary medical centers. Inclusion required a clinical diagnosis of EM, RIME, SJS or TEN and a positive COVID-19 test (rapid antigen or PCR) less than 4 weeks prior to onset of dermatologic manifestation. Data was collected at time of each patient encounter. Result(s) A total of 7 patients met criteria and had a median age of 15 years for pediatric patients (<18 years of age) and 36 years for adult patients (>18 years of age). Patients were found to have a diagnosis of RIME in 85.7% of cases. Oral mucosal involvement was the most common clinical finding (100%), followed by ocular (57.1%), urogenital (57.1%) and skin (42.9%) involvement. 71.4% of cases required hospitalization for their cutaneous eruption. No patients died from their inflammatory condition. Discussion(s) This case series highlights the development of mucocutaneous eruptions in association with COVID-19 infection. Within our cohort, RIME was the most commonly identified COVID-associated eruption. These findings provide additional evidence that abnormalities in host immune response to viral pathogens play a role in severe mucocutaneous blistering conditions. Further investigation will aid our understanding of this disease to improve diagnostics and advance targeted treatments for patients in the future.
adolescent; blister; case study; clinical article; conference abstract; coronavirus disease 2019; COVID-19 testing; diagnosis; erythema multiforme; female; hospitalization; human; immune response; infectious agent; inflammation; male; multicenter study; necrosis; nonhuman; pediatric patient; rash; skin manifestation; Stevens Johnson syndrome; antigen
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
EMBASE
Type d'étude:
Étude de cohorte
/
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Revue:
Pediatric Dermatology
Année:
2023
Type de document:
Article
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