Major neurological syndromes with COVID-19: lessons to learn
SciMedicine Journal
; 4(1):13-24, 2022.
Article
Dans Anglais
| CAB Abstracts | ID: covidwho-20240435
ABSTRACT
Objective:
Covid-19 is a highly infectious viral disease, and our understanding of the impact of this virus on the nervous system is limited. Therefore, we aimed to do a systematic analysis of the neurological manifestations.Methods:
We retrospectively studied the clinical, laboratory, and radiological findings of patients with major neurological syndromes (MNS) in Covid-19 over 6 months.Results:
We had 39 patients with major neurological syndromes (MNS). The most common MNS was cerebrovascular disease (CVD) (61.53%), in which ischemic stroke (83.33%), cortical sinus thrombosis (12.50%), and haemorrhagic stroke (4.16%) were seen. Among ischemic stroke patients, 50% had a large vessel occlusion, and 66.66% of patients with CVD had a significant residual disability. Cranial neuropathy (15.38%), GBS (10.26%), encephalitis (7.26%), and myelitis (5.12%) were the other MNS. Among the three encephalitis cases, two had CSF-Covid-19 PCR positivity and had severe manifestations and a poor outcome. Associated comorbidities included hypertension (30.76%), diabetes mellitus (12.82%), chronic kidney diseases (7.69%), and polycythaemia vera (2.56%). Lung involvement was seen in 64.1% of patients. Mortality was 17.94% in MNS with Covid-19.Conclusions:
The most common major neurological syndrome associated with Covid-19 is CVD with increased frequency of large vessel occlusion causing significant morbidity and mortality. Simultaneous lung and other systemic involvement in MNS results in a deleterious outcome.
Non-communicable Human Diseases and Injuries [VV600]; Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; human diseases; ischaemia; viral diseases; coronavirus disease 2019; cerebrovascular disorders; diabetes mellitus; encephalitis; hypertension; mortality; myelitis; kidney diseases; polycythaemia; risk factors; thromboembolism; thrombosis; Severe acute respiratory syndrome coronavirus 2; man; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; ischemia; SARS-CoV-2; viral infections; encephalomyelitis; high blood pressure; death rate; kidney disorders; nephropathy; renal diseases; polycythemia; erythrocytosis; blood clots
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
CAB Abstracts
Type d'étude:
Étude pronostique
/
Examen systématique/Méta-analyse
langue:
Anglais
Revue:
SciMedicine Journal
Année:
2022
Type de document:
Article
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