SARS-COV-2 Infection in Children and Young People in Bulgaria - A Prospective, Single-Center, Cohort Study
Acta Medica Bulgarica
; 50(2):10-19, 2023.
Article
Dans Anglais
| EMBASE | ID: covidwho-20244214
ABSTRACT
Compared to other respiratory viruses, the proportion of hospitalizations due to SARS-CoV-2 among children is relatively low. While severe illness is not common among children and young individuals, a particular type of severe condition called multisystem inflammatory syndrome in children (MIS-C) has been reported. The aim of this prospective cohort study, which followed a group of individuals under the age of 19, was to examine the characteristics of patients who had contracted SARS-CoV-2, including their coexisting medical conditions, clinical symptoms, laboratory findings, and outcomes. The study also aimed to investigate the features of children who met the WHO case definition of MIS-C, as well as those who required intensive care. A total of 270 patients were included between March 2020 and December 2021. The eligible criteria were individuals between 0-18 with a confirmed SARS-CoV-2 infection at the Infectious Disease Hospital "Prof. Ivan Kirov"in Sofia, Bulgaria. Nearly 76% of the patients were <= 12 years old. In our study, at least one comorbidity was reported in 28.1% of the cases, with obesity being the most common one (8.9%). Less than 5% of children were transferred to an intensive care unit. We observed a statistically significant difference in the age groups, with children between 5 and 12 years old having a higher likelihood of requiring intensive care compared to other age groups. The median values of PaO2 and SatO2 were higher among patients admitted to the standard ward, while the values of granulocytes and C-reactive protein were higher among those transferred to the intensive care unit. Additionally, we identified 26 children who met the WHO case definition for MIS-C. Our study data supports the evidence of milder COVID-19 in children and young individuals as compared to adults. Older age groups were associated with higher incidence of both MIS-C and ICU admissions.Copyright © 2023 P. Velikov et al., published by Sciendo.
Bulgaria; children; mis-c; SARS-CoV-2; adolescent; adult; article; asthma; blood cell count; blood oxygen tension; child; clinical feature; clinical outcome; cohort analysis; coronavirus disease 2019; degenerative disease; disease severity; granulocyte; heart disease; high throughput sequencing; human; infant; intensive care; laboratory test; length of stay; low birth weight; major clinical study; neurologic disease; newborn; obesity; oxygen saturation; oxygen therapy; pediatric multisystem inflammatory syndrome/dt [Drug Therapy]; preschool child; prospective study; real time polymerase chain reaction; rheumatic disease; Severe acute respiratory syndrome coronavirus 2; thorax radiography; antibiotic agent/dt [Drug Therapy]; antibiotic agent/pv [Special Situation for Pharmacovigilance]; anticoagulant agent/dt [Drug Therapy]; anticoagulant agent/pv [Special Situation for Pharmacovigilance]; C reactive protein/ec [Endogenous Compound]; corticosteroid/dt [Drug Therapy]; corticosteroid/iv [Intravenous Drug Administration]; corticosteroid/pv [Special Situation for Pharmacovigilance]; hemoglobin/ec [Endogenous Compound]; immunoglobulin G/ec [Endogenous Compound]; immunoglobulin M/ec [Endogenous Compound]; genetic analyzer; high throughput sequencer; nucleic acid isolation kit; PCR assay kit; polymerase chain reaction system; SARS coronavirus 2 nucleic acid test kit; CFX96 Touch; ExiPrep DX viral DNA/RNA; GeneFinder COVID-19 Plus RealAmp
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
EMBASE
Type d'étude:
Étude de cohorte
/
Études expérimentales
/
Étude observationnelle
/
Étude pronostique
/
Essai contrôlé randomisé
langue:
Anglais
Revue:
Acta Medica Bulgarica
Année:
2023
Type de document:
Article
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