Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC).
Elife
; 92020 08 17.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2155739
ABSTRACT
Temporal inference from laboratory testing results and triangulation with clinical outcomes extracted from unstructured electronic health record (EHR) provider notes is integral to advancing precision medicine. Here, we studied 246 SARS-CoV-2 PCR-positive (COVIDpos) patients and propensity-matched 2460 SARS-CoV-2 PCR-negative (COVIDneg) patients subjected to around 700,000 lab tests cumulatively across 194 assays. Compared to COVIDneg patients at the time of diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and lower platelet counts. However, as the infection evolves, COVIDpos patients distinctively show declining fibrinogen, increasing platelet counts, and lower white blood cell counts. Augmented curation of EHRs suggests that only a minority of COVIDpos patients develop thromboembolism, and rarely, disseminated intravascular coagulopathy (DIC), with patients generally not displaying platelet reductions typical of consumptive coagulopathies. These temporal trends provide fine-grained resolution into COVID-19 associated coagulopathy (CAC) and set the stage for personalizing thromboprophylaxis.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Pneumopathie virale
/
Coagulation sanguine
/
Troubles de l'hémostase et de la coagulation
/
Tests de coagulation sanguine
/
Infections à coronavirus
/
Techniques de laboratoire clinique
/
Betacoronavirus
Type d'étude:
Étude de cohorte
/
Étude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Recherche qualitative
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
/
Adulte d'âge moyen
langue:
Anglais
Année:
2020
Type de document:
Article
Pays d'affiliation:
ELife.59209
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