Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?
BMC Nephrol
; 23(1): 91, 2022 03 05.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2214547
ABSTRACT
BACKGROUND:
Antibody-mediated rejection (AMR) was described in kidney transplant patients after viral infections, such as the cytomegalovirus. Very few cases were recently reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, probably in the context of lowering of immunosuppressive therapy. To date, no direct immunological link was proved to explain a connection between the coronavirus disease 19 (COVID-19) infection and antibody-mediated rejection (AMR) if it exists. CASE PRESENTATION Here we try to find this association by presenting the case of a low immunological risk patient who presented, six years post-transplant, with c4d negative antibody mediated rejection due to an anti-HLA-C17 de novo donor specific antibody (DSA) after contracting the coronavirus disease 19. The HLA-Cw17 activated the antibody-dependent cell-mediated cytotoxicity via the KIR2DS1 positive NK cells. DISCUSSION ANDCONCLUSIONS:
This case report may prove a direct role for COVID-19 infection in AMRs in the kidney transplant recipients, leading us to closely monitor kidney transplant recipients, especially if they have "at-risk" donor antigens.Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Transplantation rénale
/
COVID-19
/
Rejet du greffon
/
Anticorps
Type d'étude:
Rapport de cas
/
Étude pronostique
Les sujets:
Covid long
Limites du sujet:
Humains
/
Mâle
/
Adulte d'âge moyen
langue:
Anglais
Revue:
BMC Nephrol
Thème du journal:
Néphrologie
Année:
2022
Type de document:
Article
Pays d'affiliation:
S12882-022-02713-x
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