Emerging Role of Neutrophil Extracellular Traps in Gastrointestinal Tumors: A Narrative Review.
Int J Mol Sci
; 24(1)2022 Dec 25.
Article
Dans Anglais
| MEDLINE | ID: covidwho-2246753
ABSTRACT
Neutrophil extracellular traps (NETs) are extracellular fibrous networks consisting of depolymerized chromatin DNA skeletons with a variety of antimicrobial proteins. They are secreted by activated neutrophils and play key roles in host defense and immune responses. Gastrointestinal (GI) malignancies are globally known for their high mortality and morbidity. Increasing research suggests that NETs contribute to the progression and metastasis of digestive tract tumors, among them gastric, colon, liver, and pancreatic cancers. This article explores the formation of NETs and reviews the role that NETs play in the gastrointestinal oncologic microenvironment, tumor proliferation and metastasis, tumor-related thrombosis, and surgical stress. At the same time, we analyze the qualitative and quantitative detection methods of NETs in recent years and found that NETs are specific markers of coronavirus disease 2019 (COVID-19). Then, we explore the possibility of NET inhibitors for the treatment of digestive tract tumor diseases to provide a new, efficient, and safe solution for the future therapy of gastrointestinal tumors.
Mots clés
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Thrombose
/
Pièges extracellulaires
/
Tumeurs gastro-intestinales
/
COVID-19
Type d'étude:
Recherche qualitative
/
Révision
Limites du sujet:
Humains
langue:
Anglais
Année:
2022
Type de document:
Article
Pays d'affiliation:
Ijms24010334
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