Differences in interleukin-6 and interleukin-17 expression in COVID-19 post-mortem lung tissue biopsy compared with noncovid- 19
Pharmacognosy Journal
; 14(6 Suppl):887-892, 2022.
Article
Dans Anglais
| CAB Abstracts | ID: covidwho-2267641
ABSTRACT
Background:
COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality.Background:
This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients.Methods:
This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure.Result:
There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05).Conclusion:
There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210], Non-communicable Human Diseases and Injuries [VV600], Diagnosis of Human Disease [VV720], Human Immunology and Allergology [VV055], Non-drug Therapy and Prophylaxis of Humans [VV710], human diseases, coronavirus disease 2019, viral diseases, pandemics, public health, interleukin 6, interleukin 17, postmortem examinations, lungs, respiratory diseases, tissues, diagnosis, diagnostic techniques, biopsy, case-control studies, observational studies, cross-sectional studies, inflammation, immunohistochemistry, immunological markers, surgery, surgical operations, man, Severe acute respiratory syndrome coronavirus 2, Indonesia, Homo, Hominidae, primates, mammals, vertebrates, Chordata, animals, eukaryotes, Severe acute respiratory syndrome-related coronavirus, Betacoronavirus, Coronavirinae, Coronaviridae, Nidovirales, positive-sense ssRNA Viruses, ssRNA Viruses, RNA Viruses, viruses, APEC countries, ASEAN Countries, high Human Development Index countries, lower-middle income countries, South East Asia, Asia, SARS-CoV-2, viral infections, autopsy, postmortem inspections, lung diseases, immunochemical markers
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
CAB Abstracts
langue:
Anglais
Revue:
Pharmacognosy Journal
Année:
2022
Type de document:
Article
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