Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study
Chemosensors
; 9(3):52, 2021.
Article
Dans Anglais
| ProQuest Central | ID: covidwho-2294877
ABSTRACT
Two inexpensive and simple methods for synthesis of carbon nanodots were applied and compared to each other, namely a hydrothermal and microwave-assisted method. The synthesized carbon nanodots were characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photoluminescence (PL), Fourier transform-infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The synthesized microwave carbon nanodots had smaller particle size and were thus chosen for better electrochemical performance. Therefore, they were used for our modification process. The proposed electrodes performance characteristics were evaluated according to the IUPAC guidelines, showing linear response in the concentration range 10−6–10−2, 10−7–10−2, and 10−8–10−2 M of tobramycin with a Nernstian slope of 52.60, 58.34, and 57.32 mV/decade for the bare, silver nanoparticle and carbon nanodots modified carbon paste electrodes, respectively. This developed potentiometric method was used for quantification of tobramycin in its co-formulated dosage form and spiked human plasma with good recovery percentages and without interference of the co-formulated drug loteprednol etabonate and excipients.
Chemistry--Physical Chemistry; carbon paste electrode; carbon nanodots; silver nanoparticles; hydrothermal and microwave assisted methods; tobramycin sulfate; Nanoparticles; Performance evaluation; Electrodes; Bacteria; X-ray diffraction; Nanomaterials; Voltammetry; Chromatography; Gram-negative bacteria; Microwaves; Silver; Synthesis; Tobramycin; Fourier transforms; COVID-19; Comparative studies; Photons; Electrochemical analysis; Personal computers; Antibiotics; Carbon; Infrared spectroscopy; Sensors; Dosage; Blood plasma; Transmission electron microscopy; Particle size; Coronaviruses; Photoluminescence; Disease transmission; Carbon dots; United Kingdom--UK; United States--US; Japan; Germany
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
ProQuest Central
langue:
Anglais
Revue:
Chemosensors
Année:
2021
Type de document:
Article
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