Customizable Fabrication Process for Flexible Carbon-Based Electrochemical Biosensors
Chemosensors
; 11(4):204, 2023.
Article
Dans Anglais
| ProQuest Central | ID: covidwho-2299578
ABSTRACT
In recent research, 3D printing has become a powerful technique and has been applied in the last few years to carbon-based materials. A new generation of 3D-printed electrodes, more affordable and easier to obtain due to rapid prototyping techniques, has emerged. We propose a customizable fabrication process for flexible (and rigid) carbon-based biosensors, from biosensor design to printable conductive inks. The electrochemical biosensors were obtained on a 50 µm Kapton® (polyimide) substrate and transferred to a 500 µm PDMS substrate, using a 3D-extrusion-based printing method. The main features of our fabrication process consist of short-time customization implementation, fast small-to-medium batch production, ease of electrochemical spectroscopy measurements, and very good resolution for an extrusion-based printing method (100 µm). The sensors were designed for future integration into a smart wound dressing for wound monitoring and other biomedical applications. We increased their sensibility with electro-deposited gold nanoparticles. To assess the biosensors' functionality, we performed surface functionalization with specific anti-N-protein antibodies for SARS-CoV 2 virus, with promising preliminary results.
Chemistry--Physical Chemistry; carbon-based electrochemical biosensors; 3D printing; flexible sensors; electrochemical impedance spectroscopy; Biocompatibility; Wounds; Antibodies; Rapid prototyping; Nanoparticles; Electrodes; Severe acute respiratory syndrome coronavirus 2; Biosensors; Nanomaterials; Three dimensional printing; Batch production; Graphene; Carbon; Inks; Proteins; Viscosity; Spectrum analysis; Substrates; Biomedical materials; Sensors; Printing; Wound healing; Chemical vapor deposition; Flexibility; Spectroscopy; 3-D printers; Glucose; Design; Silicon wafers; Customization; Kapton (trademark); Extrusion; Product development; Polyimide resins; United States--US; Japan; Finland
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
ProQuest Central
langue:
Anglais
Revue:
Chemosensors
Année:
2023
Type de document:
Article
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