Genetic risk factors associated with SARS-CoV-2 susceptibility in multiethnic populations
Journal of Biology and Today's World
; 11(4), 2022.
Article
Dans Anglais
| GIM | ID: covidwho-2304127
ABSTRACT
Susceptibility to infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the disease COVID-19, may be understood more clearly by looking at genetic variants and their associations to susceptibility phenotype. I conducted a genome-wide association study of SARS-CoV-2 susceptibility in a multiethnic set of three populations (European, African, and South Asian) from a UK BioBank clinical and genomic dataset. I estimated associations between susceptibility phenotype and genotyped or imputed SNPs, adjusting for age at enrollment, sex, and the ten top principal components of ancestry. Three genome-wide significant loci and their top associated SNPs were discovered in the European ancestry population SLC6A20 in the chr3p21.31 locus (rs73062389-A;P=2.315 x 10-12), ABO on chromosome 9 (rs9411378-A;P=2.436 x 10-11) and LZTFL1 on chromosome 3 (rs73062394;P=4.4 x 10-11);these SNPs were not found to be significant in the African and South Asian populations. A multiethnic GWAS may help elucidate further insights into SARS-CoV-2 susceptibility.
chromosomes; coronavirus disease 2019; ethnicity; genes; genetic variation; lungs; respiratory diseases; risk factors; single nucleotide polymorphism; susceptibility; viral diseases; Severe acute respiratory syndrome coronavirus 2; USA; Washington; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; APEC countries; high income countries; North America; America; OECD Countries; very high Human Development Index countries; Pacific Northwest States of USA; Pacific States of USA; Western States of USA; ethnic differences; genetic variability; genotypic variability; genotypic variation; lung diseases; SARS-CoV-2; United States of America; viral infections
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
GIM
Type d'étude:
Étude pronostique
langue:
Anglais
Revue:
Journal of Biology and Today's World
Année:
2022
Type de document:
Article
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