Circulation of respiratory viruses during the COVID-19 pandemic in The Gambia
Gates Open Research
; 6 (no pagination), 2023.
Article
Dans Anglais
| EMBASE | ID: covidwho-2315691
ABSTRACT
Background:
In many countries, non-pharmaceutical interventions to limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission resulted in significant reductions in other respiratory viruses. However, similar data from Africa are limited. We explored the extent to which viruses such as influenza and rhinovirus co-circulated with SARS-CoV-2 in The Gambia during the COVID-19 pandemic.Methods:
Between April 2020 and March 2022, respiratory viruses were detected using RT-PCR in nasopharyngeal swabs from 1397 participants with influenza-like illness. An assay to detect SARS-CoV-2 and a viral multiplex RT-PCR assay was used as previously described to detect influenza A and B, respiratory syncytial virus (RSV) A and B, parainfluenza viruses 1-4, human metapneumovirus (HMPV), adenovirus, seasonal coronaviruses (229E, OC43, NL63) and human rhinovirus. Result(s) Overall virus positivity was 44.2%, with prevalence higher in children <5 years (80%) compared to children aged 5-17 years (53.1%), adults aged 18-50 (39.5%) and >50 years (39.9%), p<0.0001. After SARS-CoV-2 (18.3%), rhinoviruses (10.5%) and influenza viruses (5.5%) were the most prevalent. SARS-CoV-2 positivity was lower in children <5 (4.3%) and 5-17 years (12.7%) than in adults aged 18-50 (19.3%) and >50 years (24.3%), p<0.0001. In contrast, rhinoviruses were most prevalent in children <5 years (28.7%), followed by children aged 5-17 (15.8%), adults aged 18-50 (8.3%) and >50 years (6.3%), p<0.0001. Four SARS-CoV-2 waves occurred, with 36.1%-52.4% SARS-CoV-2 positivity during peak months. Influenza infections were observed in both 2020 and 2021 during the rainy season as expected (peak positivity 16.4%-23.5%). Peaks of rhinovirus were asynchronous to the months when SARS-CoV-2 and influenza peaked. Conclusion(s) Our data show that many respiratory viruses continued to circulate during the COVID-19 pandemic in The Gambia, including human rhinoviruses, despite the presence of NPIs during the early stages of the pandemic, and influenza peaks during expected months.Copyright © 2023 Jarju S et al.
Influenza like illness; respiratory viruses; SARS-CoV-2; surveillance; Adenoviridae; adult; Africa; anorexia; anosmia; article; child; coinfection; common cold; coronavirus disease 2019/pc [Prevention]; coughing; diarrhea; disease surveillance; dyspnea; fatigue; female; fever; Gambia; geographic distribution; headache; hospitalization; human; Human metapneumovirus; Human parainfluenza virus 1; Human respiratory syncytial virus; Human rhinovirus; influenza; influenza A; influenza B; Influenza virus; major clinical study; male; middle aged; myalgia; nasopharyngeal swab; pandemic; pandemic influenza; prevalence; quality control; rainy season; respiratory virus; reverse transcription polymerase chain reaction; Rhinovirus; RNA extraction; seasonal variation; Severe acute respiratory syndrome coronavirus 2; sore throat; virus detection; PCR assay kit; RNA purification kit
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
EMBASE
langue:
Anglais
Revue:
Gates Open Research
Année:
2023
Type de document:
Article
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