The inspiratory activity of respiratory center and respiratory muscles strength after COVID-19.
Pulmonologiya
; 33(1):27-35, 2023.
Article
Dans Russe
| EMBASE | ID: covidwho-2318980
ABSTRACT
The respiratory pump that provides pulmonary ventilation includes the respiratory center, peripheral nervous system, chest and respiratory muscles. The aim of this study was to evaluate the activity of the respiratory center and the respiratory muscles strength after COVID-19 (COronaVIrus Disease 2019). Methods. The observational retrospective cross-sectional study included 74 post-COVID-19 patients (56 (76%) men, median age - 48 years). Spirometry, body plethysmography, measurement of lung diffusing capacity (DLCO), maximal inspiratory and expiratory pressures (MIP and MEP), and airway occlusion pressure after 0.1 sec (P0.1) were performed. In addition, dyspnea was assessed in 31 patients using the mMRC scale and muscle strength was assessed in 27 of those patients using MRC Weakness scale. Results. The median time from the COVID-19 onset to pulmonary function tests (PFTs) was 120 days. The total sample was divided into 2 subgroups 1 - P0.1 <= 0.15 kPa (norm), 2 - > 0.15 kPa. The lung volumes, airway resistance, MIP, and MEP were within normal values in most patients, whereas DLCO was reduced in 59% of cases in both the total sample and the subgroups. Mild dyspnea and a slight decrease in muscle strength were also detected. Statistically significant differences between the subgroups were found in the lung volumes (lower) and airway resistance (higher) in subgroup 2. Correlation analysis revealed moderate negative correlations between P0.1 and ventilation parameters. Conclusion. Measurement of P0.1 is a simple and non-invasive method for assessing pulmonary function. In our study, an increase in P0.1 was detected in 45% of post-COVID-19 cases, possibly due to impaired pulmonary mechanics despite the preserved pulmonary ventilation as well as normal MIP and MEP values.Copyright © Savushkina O.I. et al., 2023.
covid-19; maximum inspiratory and expiratory pressures in the oral cavity; occlusive oral pressure; pulmonary function tests; adult; airway obstruction; airway resistance; article; body plethysmography; breathing muscle; controlled study; coronavirus disease 2019; correlation analysis; cross-sectional study; diffusing capacity for carbon monoxide; dyspnea; female; human; lower respiratory tract; lung function; lung function test; lung mechanics; lung volume; major clinical study; male; middle aged; mouth cavity; muscle strength; non invasive procedure; normal value; respiration center; respiratory airflow; retrospective study; spirometry; weakness
Texte intégral:
Disponible
Collection:
Bases de données des oragnisations internationales
Base de données:
EMBASE
langue:
Russe
Revue:
Pulmonologiya
Année:
2023
Type de document:
Article
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