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In-depth virological assessment of kidney transplant recipients with COVID-19
Ilies Benotmane; Gabriela Gautier-Vargas; Maris-Josee Wendling; Peggy Perrin; Aurelie Velay; Xavier Bassand; Dimitri Bedo; Clement Baldacini; Mylene Sagnard; Dogan-Firat Bozman; Margaux Della-Chiesa; Morgane Solis; Floriane Gallais; Noelle Cognard; Jerome Olagne; Heloise Delagreverie; Louise Gontard; Baptiste Panaget; David Marx; Francoise Heibel; Laura Braun-Parvez; Bruno Moulin; Sophie Caillard; Samira Fafi-Kremer.
  • Ilies Benotmane; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France; Department of Virology, Strasbourg University Hospital, Strasbourg, Franc
  • Gabriela Gautier-Vargas; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Maris-Josee Wendling; Department of Virology, Strasbourg University Hospital, Strasbourg, France
  • Peggy Perrin; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France.; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Aurelie Velay; Department of Virology, Strasbourg University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Xavier Bassand; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Dimitri Bedo; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Clement Baldacini; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Mylene Sagnard; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Dogan-Firat Bozman; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Margaux Della-Chiesa; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Morgane Solis; Department of Virology, Strasbourg University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Floriane Gallais; Department of Virology, Strasbourg University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Noelle Cognard; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Jerome Olagne; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Heloise Delagreverie; Department of Virology, Strasbourg University Hospital, Strasbourg, France
  • Louise Gontard; Department of Virology, Strasbourg University Hospital, Strasbourg, France
  • Baptiste Panaget; Department of Virology, Strasbourg University Hospital, Strasbourg, France
  • David Marx; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Francoise Heibel; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Laura Braun-Parvez; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France
  • Bruno Moulin; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Sophie Caillard; Department of Nephrology and Transplantation, University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
  • Samira Fafi-Kremer; Department of Virology, Strasbourg University Hospital, Strasbourg, France; INSERM U1109, LabEx TRANSPLANTEX Strasbourg, France
Preprint Dans Anglais | medRxiv | ID: ppmedrxiv-20132076
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ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via RT-PCR and SARS-CoV-2 serology via ELISA and study their association with severe forms of COVID-19 and death in kidney transplant recipients. In this study we examined hospitalized kidney transplant recipients with non-severe (n = 21) and severe (n =19) COVID-19. SARS-CoV-2 nasopharyngeal and plasma viral load and serological response were evaluated based on outcomes and disease severity. Ten recipients (25%) displayed persistent viral shedding 30 days after symptom onset. The SARS-CoV-2 viral load of the upper respiratory tract was not associated with severe COVID-19, whereas the plasma viral load was associated with COVID-19 severity (p=0.0087) and mortality (p=0.024). All patients harbored antibodies the second week after symptom onset that persisted for two months. We conclude that plasma viral load is associated with COVID-19 morbidity and mortality, whereas nasopharyngeal viral load is not. SARS-CoV-2 shedding is prolonged in kidney transplant recipients and the humoral response to SARS-CoV-2 does not show significant impairment in this series of transplant recipients.
Texte intégral: Disponible Collection: Preprints Base de données: medRxiv Les sujets: Covid long langue: Anglais Année: 2020 Type de document: Preprint

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Texte intégral: Disponible Collection: Preprints Base de données: medRxiv Les sujets: Covid long langue: Anglais Année: 2020 Type de document: Preprint