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COVID-19 Clinical Characteristics and Outcomes in Children and Adolescents Hospitalized at the University Hospital of the West Indies, Jamaica in 2020-2021
Crista-Lee Shahine Berry; Roxanne Helene Melbourne-Chambers; Abigail Natalie Harrison; Joshua James Anzinger; Kelly-Ann Maxorinthia Gordon-Johnson; Varough Mohamed Deyde; Celia Dana Claire Christie.
  • Crista-Lee Shahine Berry; University of the West Indies and University Hospital of the West Indies, Kingston, Jamaica
  • Roxanne Helene Melbourne-Chambers; University of the West Indies and University Hospital of the West Indies, Mona, Kingston 7, Jamaica
  • Abigail Natalie Harrison; University of the West Indies and University Hospital of the West Indies, Mona, Kingston 7, Jamaica
  • Joshua James Anzinger; University of the West Indies and University Hospital of the West Indies, Kingston 7, Jamaica
  • Kelly-Ann Maxorinthia Gordon-Johnson; Centers for Disease Control and Prevention, Caribbean Regional Office, Kingston 7, Jamaica
  • Varough Mohamed Deyde; Centers for Disease Control and Prevention, Caribbean Regional Office, Kingston 7, Jamaica
  • Celia Dana Claire Christie; University of the West Indies and University Hospital of the West Indies, Kingston 7, Jamaica
Preprint Dans Anglais | medRxiv | ID: ppmedrxiv-21266916
Journal article
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ABSTRACT
Background and ObjectivesMultisystem inflammatory syndrome of children (MISC) carries a high attributable morbidity. We describe children aged <16 years hospitalised with COVID-19 and/or MISC, April 2020 to June 2021. MethodsAll were tested for SARS-CoV-2, infectious disease consultations performed, modified CDC criteria for MISC applied, charts reviewed and data analyzed. ResultsAmong 79 consecutive children with SARS-CoV-2, 41(52%) were hospitalised; with median age 10.5 years; Afro-Caribbean ethnicity 40(98%); males 21(51%); SARS-CoV-2 RT-PCR positivity 26 (63%), IgG/IgM positivity 7(17%), community exposures 8 (20%). MISC-cases 18 (44%) vs. non-MISC 23(56%) had fever (94% vs. 30%; p<0.01), fatigue/lethargy (41% vs. 4%; p=0.004), rhinorrhoea (28% vs. 4%; p=0.035), elevated neutrophils (100% vs. 87%; p=0.024) and [≥]4 abnormal inflammatory biomarkers 13 (72%). MISC-cases had [≥]2 organ/systems (100% vs. 35%; p<0.01), including gastrointestinal (72% vs. 17%; p<0.01), haematological/coagulopathic (67% vs. 4%; p<0.01); dermatologic (56% vs. 0%; p<0.01), cardiac (17% vs. 0%; p=0.042) with Kawasaki Syndrome (44% vs. 0%; p<0.01) and pleural effusions (17% vs. 0%; p=0.042). MISC-cases were treated with intravenous immune gammaglobulin (14, 78%), aspirin (12, 68%), steroids (9, 50%) and intensive care with non-invasive ventilation (2, 11%). One (6%) with pre-morbid illness died, the remainder recovered. ConclusionMISC was treated successfully with intravenous gammaglobulin, steroids and/or aspirin in 94% before cardiopulmonary decompensation, or need for inotropes, vasopressors, or invasive ventilation.
Texte intégral: Disponible Collection: Preprints Base de données: medRxiv langue: Anglais Année: 2021 Type de document: Preprint
Texte intégral: Disponible Collection: Preprints Base de données: medRxiv langue: Anglais Année: 2021 Type de document: Preprint