Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19.
Clin Nutr ESPEN
; 44: 466-468, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1252605
ABSTRACT
BACKGROUND & AIMS:
Systemic inflammation has been reported as a new predictor for COVID-19 outcomes. Thus, we hypothesized that ICU patients infected by COVID-19 had lower blood vitamin D levels and increased systemic inflammation. Therefore, this is the first Brazilian study to evaluate the vitamin D concentrations and NLR as a systemic inflammation in patients infected by COVID-19 admitted in ICU.METHODS:
This cross-sectional study selected twenty-six patients from COVID-19 Data Sharing/FAPESP, Brazil. Twenty-five patients were enrolled from a single hospital and those with blood vitamin D and neutrophil and lymphocyte data were included and had all available data analyzed. Patients were divided in two groups low vitamin D concentration when ≤20 ng/mL (low Vit D group, n = 8, 5M/3F, 62.7 ± 8.4 years old), and normal vitamin D when > 20 ng/mL (normal Vit D group, n = 17, 9M/8F, 74 ± 8.2 years old). Serum 25-hydroxy-vitamin D, C reactive protein (CRP), and count of neutrophils and lymphocytes concentrations were collected from COVID-19 Data Sharing/FAPESP. Statistical analyses were performed using the Prism version 5.0 and Student T test was applied to verify any difference between the groups.RESULTS:
Low vitamin D group had 15.5 ± 3.3 ng/mL of 25OH Vit D concentrations and normal vitamin D group had 35.9 ± 8.8 ng/mL. Although no difference between groups for CRP concentrations (low Vit D 4.5 ± 3.3 vs. normal Vit D 4.2 ± 4.0 mg/dL, p = 0.45), we found higher neutrophil count and NLR values in the low Vit D group when compared to normal Vit D group (low Vit D 6049.8 ± 3719.7 vs. normal Vit D 3741.8 ± 1704.1 ng/mL, p = 0.02) and (low Vit D 9.0 ± 8.6 vs. normal Vit D 4.2 ± 4.0 ng/mL, p = 0.03), respectively.CONCLUSION:
This data sharing-derived cases of COVID-19 in patients admitted at ICU showed that patients infected by COVID-19 had lower serum 25-hydroxy vitamin D and enhanced systemic inflammation when assessed by NLR values.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
COVID-19
/
Unidades de Terapia Intensiva
/
Neutrófilos
Tipo de estudo:
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
/
Ensaios controlados aleatorizados
Limite:
Feminino
/
Humanos
/
Masculino
/
Meia-Idade
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Clin Nutr ESPEN
Ano de publicação:
2021
Tipo de documento:
Artigo
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