The Spike of SARS-CoV-2: Uniqueness and Applications.
Front Immunol
; 12: 663912, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1325523
ABSTRACT
The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In this review, we have initially performed a meta-analysis of keywords associated with the S protein to frame the outline of important research findings and directions related to it. Based on this outline, we have reviewed the structure, uniqueness, and origin of the S protein of SARS-CoV-2. Furthermore, the interactions of the Spike protein with host and its implications in COVID-19 pathogenesis, as well as drug and vaccine development, are discussed. We have also summarized the recent advances in detection methods using S protein-based RT-PCR, ELISA, point-of-care lateral flow immunoassay, and graphene-based field-effect transistor (FET) biosensors. Finally, we have also discussed the emerging Spike mutants and the efficacy of the Spike-based vaccines against those strains. Overall, we have covered most of the recent advances on the SARS-CoV-2 Spike protein and its possible implications in countering this virus.
Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Glicoproteína da Espícula de Coronavírus
/
SARS-CoV-2
Tipo de estudo:
Estudo diagnóstico
/
Revisões
Tópicos:
Vacinas
Limite:
Humanos
Idioma:
Inglês
Revista:
Front Immunol
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Fimmu.2021.663912
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