Plasma convalescent decrease mortality in COVID-19 patients: a systematic review and meta-analysis.
Eur Rev Med Pharmacol Sci
; 25(14): 4841-4853, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1335542
ABSTRACT
OBJECTIVE:
To investigate the role of Convalescent Plasma (CP) in reducing mortality of COVID-19 patients. MATERIALS ANDMETHODS:
A systematic literature search was conducted from PubMed, Embase, Medrxiv, and Google Scholar from April and finalized in December 2020 using the following terms covid-19, convalescent plasma, cp, ccp, copla. The studies were screened, extracted, and evaluated by two authors independently. Comparative retrospective or prospective studies with a control group were included. Mortality was defined as the outcome of interest. Research articles not published in the English language, not available in full text, review articles, no measured outcome of interest were excluded from this study.RESULTS:
Eighteen studies were included in this meta-analysis. There were 5658 patients with 2092 patients treated with CP and 3536 patients as a control group. Forest plot showed CP use was associated with decreased mortality with OR = 0.64 (95% CI 0.49 to 0.84, p<0.001) and heterogeneity (I2)= 27.62%. Few patients experienced an adverse event, but no fatal case was reported.CONCLUSIONS:
Convalescent plasma is effective in reducing mortality of severe and critical COVID-19 with tolerable adverse effects.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Estudo de coorte
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
/
Revisões
/
Revisão sistemática/Meta-análise
Limite:
Humanos
Idioma:
Inglês
Revista:
Eur Rev Med Pharmacol Sci
Assunto da revista:
Farmacologia
/
Toxicologia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Eurrev_202107_26398
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