Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19.
Nat Biotechnol
; 40(1): 110-120, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1397879
ABSTRACT
A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Linfócitos T
/
Análise de Célula Única
/
COVID-19
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Nat Biotechnol
Assunto da revista:
Biotecnologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
S41587-021-01020-4
Similares
MEDLINE
...
LILACS
LIS