Combination of baloxavir and oseltamivir for treatment of severe influenza infection in hematopoietic cell transplant recipients: a novel treatment strategy for a high-risk population.

Angelidakis, Georgios; Khawaja, Fareed; Mulanovich, Victor E; Dailey-Garnes, Natalie; Ariza-Heredia, Ella; Chemaly, Roy F

Angelidakis, Georgios; Khawaja, Fareed; Mulanovich, Victor E; Dailey-Garnes, Natalie; Ariza-Heredia, Ella; Chemaly, Roy F.

Angelidakis G; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Khawaja F; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mulanovich VE; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dailey-Garnes N; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ariza-Heredia E; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chemaly RF; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: rfchemaly@mdanderson.org.

Microbes Infect ; 24(3): 104895, 2022.

Artigo em Inglês | MEDLINE | ID: covidwho-1487208

ABSTRACT

ABSTRACT

Baloxavir, a cap-dependent endonuclease inhibitor, was recently approved for treatment of severe influenza infections. Combining baloxavir with oseltamivir has been proposed to increase the response rate. We report 2 hematopoietic cell transplant recipients with severe influenza infections who were treated with this combination and discuss possible reasons for their different responses.

Assuntos

Transplante de Células-Tronco Hematopoéticas; Influenza Humana; Antivirais/uso terapêutico; Dibenzotiepinas; Transplante de Células-Tronco Hematopoéticas/efeitos adversos; Humanos; Influenza Humana/tratamento farmacológico; Influenza Humana/epidemiologia; Morfolinas; Oseltamivir/uso terapêutico; Piridonas; Transplantados; Triazinas

Palavras-chave

Baloxavir; Combination therapy; HCT; Influenza; Oseltamivir

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Influenza Humana Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Microbes Infect Assunto da revista: Alergia e Imunologia / Microbiologia Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: J.micinf.2021.104895

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