The relationship between COVID-19 viral load and disease severity: A systematic review.
Immun Inflamm Dis
; 10(3): e580, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1568102
ABSTRACT
INTRODUCTION:
Patients with COVID-19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID-19 is still unknown. Therefore, this study aimed to systematically review the association between SARS-CoV-2 viral load and COVID-19 severity.METHODS:
The relevant studies using the keywords of "COVID-19" and "viral load" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. A two-step title/abstract screening process was carried out and the eligible studies were included in the study.RESULTS:
Thirty-four studies were included from the initial 1015 records. The vast majority of studies have utilized real-time reverse transcription-polymerase chain reaction of the nasopharyngeal/respiratory swabs to report viral load. Viral loads were commonly reported either as cycle threshold (Ct ) or log10 RNA copies/ml.CONCLUSION:
The results were inconclusive about the relationship between COVID-19 severity and viral load, as a similar number of studies either approved or opposed this hypothesis. However, the studies denote the direct relationship between older age and higher SARS-CoV-2 viral load, which is a known risk factor for COVID-19 mortality. The higher viral load in older patients may serve as a mechanism for any possible relationships between COVID-19 viral load and disease severity. There was a positive correlation between SARS-CoV-2 viral load and its transmissibility. Nonetheless, further studies are recommended to precisely characterize this matter.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Revisões
/
Revisão sistemática/Meta-análise
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Immun Inflamm Dis
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Iid3.580
Similares
MEDLINE
...
LILACS
LIS