Variant-specific SARS-CoV-2 within-host kinetics.
J Med Virol
; 94(8): 3625-3633, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1772792
ABSTRACT
Since early 2021, SARS-CoV-2 variants of concern (VOCs) have been causing epidemic rebounds in many countries. Their properties are well characterized at the epidemiological level but the potential underlying within-host determinants remain poorly understood. We analyze a longitudinal cohort of 6944 individuals with 14 304 cycle threshold (Ct) values of reverse-transcription quantitative polymerase chain reaction (RT-qPCR) VOC screening tests performed in the general population and hospitals in France between February 6 and August 21, 2021. To convert Ct values into numbers of virus copies, we performed an additional analysis using droplet digital PCR (ddPCR). We find that the number of viral genome copies reaches a higher peak value and has a slower decay rate in infections caused by Alpha variant compared to that caused by historical lineages. Following the evidence that viral genome copies in upper respiratory tract swabs are informative on contagiousness, we show that the kinetics of the Alpha variant translate into significantly higher transmission potentials, especially in older populations. Finally, comparing infections caused by the Alpha and Delta variants, we find no significant difference in the peak viral copy number. These results highlight that some of the differences between variants may be detected in virus load variations.
Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Estudo de coorte
/
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Variantes
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
J Med Virol
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Jmv.27757
Similares
MEDLINE
...
LILACS
LIS